Non Viral Vectors in Gene Therapy- An Overview GE01-GE06
Correspondence
Dr. Murali Ramamoorthi,
Apt-4,4435 Rue Sherbrooke West, Montreal, Quebec, H3Z 1E5, Canada.
Phone : +1-514-980-2511, E-mail : murali.ramamoorthi@mail.mcgill.ca
Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and extracellular barriers, number of other challenges also needs to be overcome in order to increase the effectiveness of non-viral gene transfer. These barriers are categorized as production, formulation and storage. No one-size-fits-all solution to gene delivery, which is why in spite of various developments in liposome, polymer formulation and optimization, new compounds are constantly being proposed and investigated. In this review, we will see in detail about various types of non-viral vectors highlighting promising development and recent advances that had improved the non-viral gene transfer efficiency of translating from “Bench to bedside”.