Changes in Transforming Growth Factor-ß1 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis Following Periodontal Flap Surgery ZC13-ZC16
Correspondence
Dr. Vignesh Vikram,
PG Student, Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai-95, India.
E-mail: vigneshvikram87@gmail.com
Introduction: The aim of the study was to assess changes in Transforming Growth Factor– ß 1 (TGF- ß 1) levels in gingival crevicular fluid (GCF) and examine correlation of TGF- ß 1 levels and periodontal parameters: probing pocket depth (PPD) and clinical attachment level (CAL) in sites with chronic periodontitis at various time intervals before and after periodontal surgery.
Materials and Methods: The effects of non-surgical and surgical therapy on periodontal parameters and GCF TGF- ß 1 levels in 18 sites affected with chronic periodontitis were assessed upto 6 weeks post conventional flap surgery. GCF was collected and PPD, CAL recorded at Baseline. GCF was collected and PPD, CAL recorded at Pre-surgery and flap surgery performed. GCF was collected from all sites at Two Weeks Post-surgery. GCF was collected and PPD, CAL recorded at Six Weeks Post-surgery. The concentration of TGF- ß 1 in GCF was determined using a human TGF- ß 1 enzyme immunometric assay kit.
Results: Mean TGF- ß 1 concentrations were significantly reduced at Pre-surgery, at Two Weeks Post-surgery and at Six Weeks Post-surgery (p<0.05) when compared to Baseline TGF- ß 1 values. There was a statistically significant reduction in PPD and gain in CAL following non-surgical and surgical therapy when compared to baseline (p<0.05).
Conclusion: Results indicate that TGF- ß 1 may play a role in the pathogenesis and diagnosis of periodontal disease and could be considered as a disease predictive biomarker.