Refractory Thrombotic Thrombocytopenic Purpura: A Case Report OD01-OD02
Dr. Prabu Pandurangan,
Greams Road, Apollo Hospital, Chennai-600001, Tamil Nadu, India.
Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy. Clinical manifestations occur due to decreased perfusion to the internal organs. Usually it responds to pulse steroids and plasma exchange. Various therapies are available for refractory cases which respond to N-Acetyl cysteine, cyclosporin, rituximab, bortezomib and caplacizumab. We report a case of refractory Thrombotic Thrombocytopenic Purpura (TTP) in a 29-years-old female showed improvement with the use of rituximab (anti-CD 20 monoclonal antibody), who presented with history of fever and one episode of seizure.