The Effect of Carvedilol on Blood Glucose Levels In Normal Albino RatsCorrespondence Address :
Dr. Suresha R.N.,
Professor and Head, Department of Pharmacology, JSS Medical College,
JSS University, SS Nagar, Mysore, Karnataka–570015, India.
Phone: 08123466041, E-mail: email@example.com
Background: Carvedilol is a commonly used drug in hypertension, congestive heart failure in diabetics. It has moderate calcium channel blocking property in addition to a1 and non selective ß antagonistic activity. Though some studies bring forth the beneficial effects of Carvedilol in cardiovascular comorbidities in diabetes, there is no consensus on its effects on glycaemic levels.
Aims: To evaluate the effect of oral Carvedilol administration for 5 days on blood glucose levels in normal albino rats through Oral Glucose Tolerance Test. Material and Methods: Twelve adult albino rats of either sex weighing between 150 – 200 g were selected from central animal facility and randomly divided into 2 groups – Control [Distilled water (1ml/rat orally)] and Test (0.8mg/kg body weight orally) and the respective drugs were administered over 5 days. Following overnight fasting, on the fifth day 1 hour after the last dose of the respective drug, OGTT was performed. The CBG (Capillary Blood Glucose) levels were measured at 0 min, glucose (2g/kg body weight) dissolved in water was administered to all the rats orally. The blood sample from tail vein (obtained by tail snipping) at 60 and 150 minutes were analysed for CBG levels using a standardized glucometer. Statistical Analysis: Data was presented as Mean ± SEM. One way ANOVA, independent samples t-test, non–parametric tests, percentages and cross tabs were used in the analysis of data within the same group and between different groups when required.
Results: Carvedilol group showed higher CBG levels at all time intervals of OGTT as compared to the Control group i.e., 0, 60 and 150 minutes, the highest being (103.8±5.029 )mg/dl at 60 minutes and was statistically significant. Carvedilol group however showed lesser inter–interval variation compared to the Control group at the same time intervals respectively but was statistically insignificant.
Conclusions: Carvedilol has hyperglycaemic potential when given orally for 5 days in normal albino rats. Though it may be beneficial in diabetics for various comorbid conditions, the glycaemic control may worsen during its use in subjects with prediabetes, diabetes, high risk diabetes.
Carvedilol, Calcium channel blocker, Oral glucose tolerance test, Hyperglycaemia, Diabetes mellitus, Drug induced hyperglycaemia
Suresha R.N., Ashwini V., Pragathi B., Kalabharathi H.L., Satish A.M., Pushpa V.H., et al.. THE EFFECT OF CARVEDILOL ON BLOOD GLUCOSE LEVELS IN NORMAL ALBINO RATS. Journal of Clinical and Diagnostic Research [serial online] 2013 September [cited: 2018 Feb 24 ]; 7:1900-1903. Available from
Financial OR OTHER COMPETING INTERESTS: None.
Date of Submission: May 09, 2013
Date of Peer Review: Jun 24, 2013
Date of Acceptance: Aug 04, 2013
Date of Publishing: Sept 10, 2013
- Emerging Sources Citation Index (Web of Science, thomsonreuters),
- Index Copernicus ICV 2016: 132.37,
- Academic Search Complete Database,
- Directory of Open Access Journals (DOAJ),
- Embase & EMbiology ,
- Google Scholar,
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA),
- Journal seek Database,
- Popline (reproductive health literature),