Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 CasesCorrespondence Address :
Dr. Mingma Sherpa,
Associate Professor, Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Gangtok-737102, Sikkim, India.
Email : email@example.com
Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesions.
Aim: The objective of this study was to reveal the cytological characteristics of DQT.
Materials and Methods: We retrospectively reviewed the clinical and FNAC findings of 20 cases of DQT to find the most reliable features for a confident cytological diagnosis.
Results: Among the cases reviewed, the common cytological features present in all 20 cases were follicular epithelial cells with degenerative changes and dirty background comprising of cellular debris and mixed inflammatory cells (lymphocytes and macrophages and occasional polymorphs). The next common finding observed was Multinucleated Giant Cells (MNGCs) seen in 19 cases followed by epithelioid cell clusters in 15 and colloid in 13 cases.
Conclusion: Presence of follicular epithelial cells, large MNGCs and dirty background of cellular debris, mixed inflammatory cells with predominance of lymphocytes and macrophages were the most striking and consistent features for diagnosis of DQT in cytological smears. The above findings in consideration with the clinical history will help us reach a definitive diagnosis. FNA also proves to be a useful tool in excluding other thyroid lesions with similar clinical presentations.
Cytology, Degenerated follicular epithelial cells, Multinucleated giant cells
Rachna Lamichaney, Mingma Sherpa, Deepak Das, Chumila Thinley Bhutia, Sabina Laishram. FINE-NEEDLE ASPIRATION OF DE QUERVAIN'S THYROIDITIS (SUBACUTE GRANULOMATOUS THYROIDITIS): A CYTOLOGICAL REVIEW OF 20 CASES. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Nov 25 ]; 11:EC09-EC11. Available from
Date of Submission: Dec 16, 2016
Date of Peer Review: Feb 06, 2017
Date of Acceptance: May 15, 2017
Date of Publishing: Aug 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)