Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : August | Volume : 11 | Issue : 8 | Page : OC11 - OC14

Visceral Adiposity Index and the Degree of Hepatic Fibrosis and Inflammation in Egyptian Patients with Chronic Hepatitis C

Zainab ahmed ali-eldin, fatma ahmed ali-eldin, inas elkhedr mohamed

1. Assistant Professor, Department of Internal Medicine, Ain Shams University, Cairo, Egypt. 2. Assistant Professor, Department of Tropical Medicine, Ain Shams University, Cairo, Egypt. 3. Assistant Professor, Department of Internal Medicine, Ain Shams University, Cairo, Egypt.

Correspondence Address :
Dr. Inas Elkhedr Mohamed,
14 Alzohour street, Orouba, Nozha, Cairo, Egypt.
E-mail: inas_elkhedr@yahoo.com

Abstract

Introduction: Many clinical studies suggest a direct association between hepatic fat content and visceral adiposity and the progression of fibrosis.

Aim: This work aims to clarify the relation between the Visceral Adiposity Index (VAI) and severity of necroinflammatory activity and liver fibrosis in Egyptian patients with chronic Hepatitis C Virus (HCV) infection.

Materials and Methods: A cross-sectional study, over a period of six months, was performed on 50 chronic HCV patients subjected to routine laboratory investigations, abdominal ultrasonography, measurement of Waist Circumference (WC), calculation of Body Mass Index (BMI) and VAI, ultrasound guided liver biopsy and assessment of hepatic fibrosis by METAVIR staging.

Results: A total of 50 HCV positive patients, 29 (58%) males and 21 (42%) females were included in the study. Age ranged from 29-60 years (44.4±8.4). BMI was ranged from 20.3 to 41.4 kg/m2 (31.7±5.5). VAI for males was 0.4±0.2 and for females was 0.5±0.3. There were significant positive correlations between VAI and BMI, Triglycerides (TG), fibrosis stages, grades of liver inflammation and FIB-4 Fibrosis-4 score. There were significant negative correlations between VAI and high density lipoprotein, platelets and haemoglobin.

Conclusion: There is an association between visceral obesity represented by VAI and the severity of hepatic inflammatory response in chronic hepatitis C patients. Other studies are recommended to measure the clinical implication of visceral obesity on the response to the novel directly acting antivirals.

Keywords

Liver fibrosis, Viral hepatitis, Visceral obesity

How to cite this article :

Zainab ahmed ali-eldin, fatma ahmed ali-eldin, inas elkhedr mohamed. VISCERAL ADIPOSITY INDEX AND THE DEGREE OF HEPATIC FIBROSIS AND INFLAMMATION IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Sep 20 ]; 11:OC11-OC14. Available from
http://jcdr.in/back_issues.asp?issn=0973-709x&year=2017&month=August&volume=11&issue=8&page=OC11-OC14&id=10330

DOI and Others

DOI: 10.7860/JCDR/2017/28381.10330


Date of Submission: Mar 17, 2017
Date of Peer Review: May 12, 2017
Date of Acceptance: Jun 27, 2017
Date of Publishing: Aug 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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