Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2018 | Month : March | Volume : 12 | Issue : 3 | Page : OD01 - OD02

Refractory Thrombotic Thrombocytopenic Purpura: A Case Report

Mohammed Shafi Abdulsalam, Venkateshwaran Radhakrishnan, Prabu Pandurangan

1. Former Registrar, Department of Haematology, Apollo Hospital,Chennai, Tamil Nadu, India. 2. Postgraduate Student, Department of General Medicine, Apollo Hospital, Chennai, Tamil Nadu, India. 3. Senior Consultant Haematologist, Department of Haematology, Apollo Hospital, Chennai, Tamil Nadu, India.

Correspondence Address :
Dr. Prabu Pandurangan,
Greams Road, Apollo Hospital, Chennai-600001, Tamil Nadu, India.


Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy. Clinical manifestations occur due to decreased perfusion to the internal organs. Usually it responds to pulse steroids and plasma exchange. Various therapies are available for refractory cases which respond to N-Acetyl cysteine, cyclosporin, rituximab, bortezomib and caplacizumab. We report a case of refractory Thrombotic Thrombocytopenic Purpura (TTP) in a 29-years-old female showed improvement with the use of rituximab (anti-CD 20 monoclonal antibody), who presented with history of fever and one episode of seizure.


N-Acetyl cysteine, Rituximab, Splenectomy

How to cite this article :

Mohammed Shafi Abdulsalam, Venkateshwaran Radhakrishnan, Prabu Pandurangan. REFRACTORY THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2018 March [cited: 2018 Aug 21 ]; 12:OD01-OD02. Available from

DOI and Others

DOI: 10.7860/JCDR/2018/28444.11237

Date of Submission: Mar 18, 2017
Date of Peer Review: May 17, 2017
Date of Acceptance: Jan 16, 2018
Date of Publishing: Mar 01, 2018


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