Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies
Correspondence Address :
Seetu Palo,
Department of Pathology and Laboratory Medicine, All India Institute of Medical
Sciences, Bibinagar, Hyderabad Metropolitan Region, India.
E-mail: seetu.pearl@gmail.com
Coronavirus Disease 2019 (COVID-19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although, there are rapidly increasing number of studies on epidemiologic characteristics and clinical aspects of COVID-19, its pathology still remains a largely unexplored territory, mainly due to limited autopsy studies. Autopsy studies are essential to demonstrate the spectrum of COVID-19-associated organ changes. This article reviews and highlights the important histopathological findings observed in different organ systems as evident from various published and anecdotal reports from across the world. Major histopathological findings in the lungs include different stages of Diffuse Alveolar Damage (DAD) and microthrombi along with variable degree of inflammation. Microscopic analysis of renal parenchyma may show acute tubular injury and fibrin thrombi in the glomerular capillaries. Heart, liver and brain show no significant inflammatory changes.
Acute tubular injury, Coronavirus disease 2019, Diffuse alveolar damage, Microthrombi, Severe acute respiratory syndrome coronavirus-2
DOI: 10.7860/JCDR/2021/47604.14675
Date of Submission: Nov 02, 2020
Date of Peer Review: Dec 18, 2020
Date of Acceptance: Jan 14, 2021
Date of Publishing: Apr 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 04, 2020
• Manual Googling: Jan 13, 2021
• iThenticate Software: Mar 16, 2021 (15%)
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